JAK1 Antibody (Phospho-Tyr1022)

Polyclonal Antibody

Autophosphorylated. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling. Ubiquitinated by RNF125; leading to its degradation by the proteasome.

132 kDa

JAK1

Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

JAK1 is a protein encoded by the JAK1 gene which is approximately 133, 2 kDa. JAK1 is localised to the endomembrane system. It is involved in RET signalling, Th17 cell differentiation, influenza A and IL27-mediated signalling events. It is a membrane protein that is a member of a class of protein-tyrosine kinases characterized by the presence of a second phosphotransferase-related domain at the N-terminal to the PTK domain. It plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. JAK1 is expressed in the nervous system, liver, blood, spleen and lung. Mutations in the JAK1 gene may result in chilblain lupus and T-cell prolymphocytic leukemia. STJ90314 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous JAK1 protein which only binds about Y1022 when Y1022 is phosphorylated.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Phospho-JAK1 (Y1022) Polyclonal Antibody detects endogenous levels of JAK1 protein only when phosphorylated at Y1022.