FLRT3 ELISA Kit (Human) (OKCD00701)

leucine-rich repeat transmembrane protein FLRT3

23767

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).By similarity < p>Manually curated information which has been propagated from a related experimentally characterized protein.< /p> < p>< a href="/manual/evidences#ECO:0000250">Moreâa‚¬A< /a>< /p> Manual assertion inferred from sequence similarity toiUniProtKB:B1H234  (FLRT3_RAT)UniProtKB:Q8BGT1  (FLRT3_MOUSE)2 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.9"FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth."_x005F_x000D_ Tsuji L., Yamashita T., Kubo T., Madura T., Tanaka H., Hosokawa K., Tohyama M._x005F_x000D_ Biochem. Biophys. Res. Commun. 313:1086-1091(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.Ref.11"Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion."_x005F_x000D_ Lu Y.C., Nazarko O.V., Sando R. III, Salzman G.S., Suedhof T.C., Arac D._x005F_x000D_ Structure 23:1678-1691(2015) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 29-357 IN COMPLEX WITH ADGRL3, SUBUNIT, INTERACTION WITH ADGRL3; UNC5B AND UNC5D, SUBCELLULAR LOCATION, DISULFIDE BOND, GLYCOSYLATION AT ASN-226, MUTAGENESIS OF ASP-38; TYR-43; ASN-45; ARG-47; TYR-64; TYR-89; TYR-91; ARG-181 AND ASP-183.

< 0.57 ng/mL