Vergleich

SHC1 Peptide (AAP50490)

ArtNr AAP50490
Hersteller AVIVA Systems Biology
Menge 100 ug
Kategorie
Typ Peptides
Format Lyophilized powder
Applikationen WB
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
Similar products SHC1
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Description
This is a synthetic peptide designed for use in combination with anti-SHC1 antibody (Catalog #: ARP50490_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Gene symbol
SHC1
Protein size
474
Molecular weight
52kDa
Product format
Lyophilized powder
Gene id
6464
Reconstitution and storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Partner proteins
AXL, DDR1, EGFR, EGFR, EGFR, EGFR, GRB2, GRB2, IGF1R, INPP5D, INSR, ITGB3, NTRK1, NTRK1, PDGFRB, PDGFRB, RET, SRC, IRS1, PDGFRB, NTRK1, ALK, AP2A1, AP2A2, APP, AXL, BCL3, BCR, CALCOCO2, CALD1, CBL, CBLB, CD22, CD247, CD3E, CD81, CDH5, CEACAM1, CRK, CRKL, CSF1R, CSF2RB, CSF3R, CSK, DAG1, DDR1, DDR2, DOK1, EGFR, EPHA2, EPOR, EPS8, ERBB2, ERBB3, ERBB4, ESR1, FCGR2A, FCGR3A, FGFR1, FLT1, FLT4, FYN, GAB1, GAB2, GHR, GRAP, GRAP2, GRB2, GRB7, IL2, IL2RB, IL2RG, IL4R, INPP5D, INPPL1, INSR, IRS1, IRS2, ITGB3, ITGB4, JAK2, KDR, KRT18, LCK, LCP2, LRP1, LTK, LYN, MAP4K1, MAPK1, MAPK14, MAPK8, MAPKAPK2, MET, MME, MPL, MST1R, NGFR, NPM1, NTRK1, NTRK2, NTRK3, PAG1, PAK1, PDGFRB, PIK3R1, PIK3R2, PLCG1, PLCG2, PLSCR1, PPAP2B, PPP2R5A, PRKCA, PRKCD, PTK2, PTK2B, PTPN11, PTPN12, PTPN2, PTPN6, RAPGEF1, RASA1, RET, SH2B2, SHCBP1, SOS1, SOS2, SP1, SRC, STAT5A, STAT5B, SYK, TEC, TEK, TPR, VAV1, VAV3, ZAP70, GRB2, ABL1, ALK, AP2A2, APP, CALCOCO2, CALD1, CBL, CBLB, CD22, CDH5, CEACAM1, CRKL, CSF2RB, CSF3R, CSK, Cd3e, DAG1, DDR1, DDR2, DOK1, DOK2, EGFR, EPHA2, EPOR, EPS8, ERBB2, ERBB3, ERBB4, ESR1, FCGR2B, FLT1, FLT4, GAB2, GH1, GHR, GRB2, Gab2, Grap2, IGF1R, IL2RB, IL2RG, IL4R, IL6ST, INPP5D, INPPL1, INSR, IRS1, ITGB4, JAK2, KDR, LRP1, LYN, MAPK1, MAPKAPK2, MET, MST1R, NGFR, NTRK1, NTRK2, NTRK3, PAG1, PDGFRB, PIK3C2B, PIK3R1, PIK3R1, PLCG1, PLCG2, PLSCR1, PRKCD, PTK2, PTK2, PTPN12, Ptpn12, RAPGEF1, RET, SHCBP1, SOS1, SOS2, STAT5A, STAT5B, VAV3, ZAP70
Description of target
SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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