Comparison

SHC1 Peptide (AAP50490)

Item no. AAP50490
Manufacturer AVIVA Systems Biology
Amount 100 ug
Category
Type Peptides
Format Lyophilized powder
Applications WB
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
Similar products SHC1
Available
Description
This is a synthetic peptide designed for use in combination with anti-SHC1 antibody (Catalog #: ARP50490_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Gene symbol
SHC1
Protein size
474
Molecular weight
52kDa
Product format
Lyophilized powder
Gene id
6464
Reconstitution and storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Partner proteins
AXL, DDR1, EGFR, EGFR, EGFR, EGFR, GRB2, GRB2, IGF1R, INPP5D, INSR, ITGB3, NTRK1, NTRK1, PDGFRB, PDGFRB, RET, SRC, IRS1, PDGFRB, NTRK1, ALK, AP2A1, AP2A2, APP, AXL, BCL3, BCR, CALCOCO2, CALD1, CBL, CBLB, CD22, CD247, CD3E, CD81, CDH5, CEACAM1, CRK, CRKL, CSF1R, CSF2RB, CSF3R, CSK, DAG1, DDR1, DDR2, DOK1, EGFR, EPHA2, EPOR, EPS8, ERBB2, ERBB3, ERBB4, ESR1, FCGR2A, FCGR3A, FGFR1, FLT1, FLT4, FYN, GAB1, GAB2, GHR, GRAP, GRAP2, GRB2, GRB7, IL2, IL2RB, IL2RG, IL4R, INPP5D, INPPL1, INSR, IRS1, IRS2, ITGB3, ITGB4, JAK2, KDR, KRT18, LCK, LCP2, LRP1, LTK, LYN, MAP4K1, MAPK1, MAPK14, MAPK8, MAPKAPK2, MET, MME, MPL, MST1R, NGFR, NPM1, NTRK1, NTRK2, NTRK3, PAG1, PAK1, PDGFRB, PIK3R1, PIK3R2, PLCG1, PLCG2, PLSCR1, PPAP2B, PPP2R5A, PRKCA, PRKCD, PTK2, PTK2B, PTPN11, PTPN12, PTPN2, PTPN6, RAPGEF1, RASA1, RET, SH2B2, SHCBP1, SOS1, SOS2, SP1, SRC, STAT5A, STAT5B, SYK, TEC, TEK, TPR, VAV1, VAV3, ZAP70, GRB2, ABL1, ALK, AP2A2, APP, CALCOCO2, CALD1, CBL, CBLB, CD22, CDH5, CEACAM1, CRKL, CSF2RB, CSF3R, CSK, Cd3e, DAG1, DDR1, DDR2, DOK1, DOK2, EGFR, EPHA2, EPOR, EPS8, ERBB2, ERBB3, ERBB4, ESR1, FCGR2B, FLT1, FLT4, GAB2, GH1, GHR, GRB2, Gab2, Grap2, IGF1R, IL2RB, IL2RG, IL4R, IL6ST, INPP5D, INPPL1, INSR, IRS1, ITGB4, JAK2, KDR, LRP1, LYN, MAPK1, MAPKAPK2, MET, MST1R, NGFR, NTRK1, NTRK2, NTRK3, PAG1, PDGFRB, PIK3C2B, PIK3R1, PIK3R1, PLCG1, PLCG2, PLSCR1, PRKCD, PTK2, PTK2, PTPN12, Ptpn12, RAPGEF1, RET, SHCBP1, SOS1, SOS2, STAT5A, STAT5B, VAV3, ZAP70
Description of target
SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

Delivery expected until 10/9/2025 

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