CCL27 Protein

ArtNr	OPCB00009
Hersteller	AVIVA Systems Biology
Menge	5 ug
Kategorie	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized
Specific against	other
Purity	> 97% as determined by SDS-PAGE
Sequence	The protein sequence is: <a href='//www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_SEQUENCE=on&NCBI_GI=on&ALIGNMENTS=50
Citations	1. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Homey et al. Nature Med. 8: 157-165 (2002) 2. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. Ishikawa-Mochizuki et al. FEBS Lett. 460:544-548 (1999) 3. The Chemokine ESkine/CCL27 Displays Novel Modes of Intracrine and Paracrine Function Gortz A. etal. J Immunol. 169:1387-1394 (2002)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ALP,ILC,CTAK,CTACK,PESKY,ESKINE,SCYA27
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	10.149kDa
Gene symbol	CCL27
Gene Fullname	chemokine (C-C motif) ligand 27
Product format	Lyophilized
Reconstitution and storage	Spin tube prior to resuspending. Recommended at 100ug/mL in sterile water Shipping: Room Temp
Description of target	Cutaneous T-cell-attracting chemokine (CTACK)(CCL27) is a ligand for cell surface receptor CCR10. It is responsible for chemotaxis of skin-homing memory T cells during cutaneous inflammation. Interestingly, after CCR10-mediated internalization, CTACK, as well as a non-secreted splice variant of the same gene, can reach the nucleus and modulate transcription and cell behavior.
Biological activity	EC50 = 34nM determined by Migration Assay in cells expressing recombinant CCR10

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