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CCL27 Protein

CCL27 Protein

Item no.	OPCB00009
Manufacturer	AVIVA Systems Biology
Amount	5 ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
Purity	> 97% as determined by SDS-PAGE
Sequence	The protein sequence is: <a href='//www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_SEQUENCE=on&NCBI_GI=on&ALIGNMENTS=50
Citations	1. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Homey et al. Nature Med. 8: 157-165 (2002) 2. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. Ishikawa-Mochizuki et al. FEBS Lett. 460:544-548 (1999) 3. The Chemokine ESkine/CCL27 Displays Novel Modes of Intracrine and Paracrine Function Gortz A. etal. J Immunol. 169:1387-1394 (2002)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ALP,ILC,CTAK,CTACK,PESKY,ESKINE,SCYA27
Shipping Condition	Cool pack
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	10.149kDa
Gene symbol	CCL27
Gene Fullname	chemokine (C-C motif) ligand 27
Product format	Lyophilized
Reconstitution and storage	Spin tube prior to resuspending. Recommended at 100ug/mL in sterile water Shipping: Room Temp
Description of target	Cutaneous T-cell-attracting chemokine (CTACK)(CCL27) is a ligand for cell surface receptor CCR10. It is responsible for chemotaxis of skin-homing memory T cells during cutaneous inflammation. Interestingly, after CCR10-mediated internalization, CTACK, as well as a non-secreted splice variant of the same gene, can reach the nucleus and modulate transcription and cell behavior.
Biological activity	EC50 = 34nM determined by Migration Assay in cells expressing recombinant CCR10

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 ug

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Delivery expected until 12/25/2025

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