IL 13 Protein (OPPA00637)

Hersteller AVIVA Systems Biology
Kategorie
Typ Proteins
Specific against other
Format The protein (1mg/ml) was lyophilized with no additives. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Menge 2ug
Host E.coli
ArtNr OPPA00637
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene symbol
IL-13
Protein name
Interleukin-13
Product format
The protein (1mg/ml) was lyophilized with no additives. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Gene id
16163
Reconstitution and storage
Reconstitution: It is recommended to reconstitute the lyophilized Interleukin 13 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Storage: Lyophilized Interleukin-13 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IL13 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
Description of target
IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Purification
The IL-13 is purified by proprietary chromatographic techniques.
Biological activity
The ED50 range=4 ng/ml, corresponding to a specific activity of 250, 000IU/mg as determined by the dose dependent proliferation of TF-1 cells.
Purity
Greater than 95% as determined by SDS-PAGE.

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Menge: 2ug
Lieferbar: In stock
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