IL 13 Protein

Root Catalog/Products/Recombinant Proteins

IL-13

The protein (1mg/ml) was lyophilized with no additives. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

Interleukin-13

The ED₅₀ range=4 ng/ml, corresponding to a specific activity of 250, 000IU/mg as determined by the dose dependent proliferation of TF-1 cells.