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ENSA Protein (OPPA02085)

ENSA Protein (OPPA02085)

Hersteller	AVIVA Systems Biology
Kategorie	Proteins
Typ	Proteins
Specific against	other
Format	The Endosulfine Alpha protein solution contains 20mM Tris, pH-8, 1mM DTT and 10% glycerol. Physical appearance: Sterile filtered colorless solution.
Menge	5ug
Host	E.coli
ArtNr	OPPA02085
eClass 6.1	34160400
eClass 9.0	42020190
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Gene symbol	ENSA
Protein name	Alpha-endosulfine
Product format	The Endosulfine Alpha protein solution contains 20mM Tris, pH-8, 1mM DTT and 10% glycerol. Physical appearance: Sterile filtered colorless solution.
Gene id	2029
Reconstitution and storage	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description of target	ENSA is an endogenous ligand for sulfonylurea receptor. ENSA reduces K(ATP) channel currents by inhibiting sulfonylurea from binding to the receptor and thus stimulates insulin secretion. Endosulfine Alpha is part of a conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine Alpha is an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. Endosulfine Alpha is an endogenous regulator of KATP channels. ENSA modulates insulin secretion through the interaction with KATP channel. ENSA is a candidate gene for type 2 diabetes. ENSA is expressed in a wide range of tissues including muscle, brain, and endocrine tissues.
Purification	The ENSA is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Purity	Greater than 90.0% as determined by SDS-PAGE.
Drywet	Wet Ice

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