Hersteller |
Biomatik
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Human |
Menge |
100ug |
ArtNr |
BM-RPC20810-100ug |
Targets |
IGBP1 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Gene Name |
CNGA4 |
Alternative Names |
Cyclic nucleotide-gated channel alpha-4 Short name: CNG channel alpha-4 Short name: CNG-4 Short name: CNG4 |
Uniprot |
Q8IV77 |
Source |
in vitro E.coli expression system |
Expression Region |
1-575aa |
AA Sequence |
MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYY WWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWL VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRI SSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLR LNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLY IFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPG FERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYL FMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFY PDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKK MTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQ NCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEM YIIREGQLAVVADDGITQYAVLGAGLYFGEISIIN IKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLS EYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQ EATESRLRGLDQQLDDLQTKFARLLAELESSALKI AYRIERLEWQTREWPMPEDLAEADDEGEPEEGTSK DEEGRASQEGPPGPE |
Sequence Info |
Full Length |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
Theoretical MW |
82 kDa |
Purity |
>90% as determined by SDS-PAGE. |
Storage Buffer |
Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Endotoxin Level |
Not tested |
Biological Activity |
Not tested |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). |
Function |
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). |
Subcellular location |
Membrane, Multi-pass membrane protein |
Protein Families |
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA4 subfamily |
Paythway |
cAMPsignalingpathway |
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