Vergleich

Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a

ArtNr M-009-100
Hersteller Biosensis
Menge 100ug
Kategorie
Typ Antibody Monoclonal
Applikationen WB, IF
Clon MLR2
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG2a
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Similar products Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, p75 ICD, NGF receptor
Lieferbar
Sub category
Neurotrophic Factor Receptors-Sensory Nervous System-Stem Cells
products_extra_fields_value
p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3.
products_quantity
200
storage
After reconstitution keep aliquots at -20AC for a higher stability, and at 4AC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
purityisotype
Protein G purified immunoglobulin
formulation
Lyophilised from PBS pH 7.4
immunogen
This antibody was raised against chimeric recombinant human p75 protein coupled to an Fc region of human immunoglobulin.
crossreactivity
This antibody is known to react with human, mouse, rat and guinea-pig p75NTR protein.
conality
Mouse
specificity
Specificity has been confirmed using a number of techniques as described in the reference by Rogers et al (2006). The antibody recognizes extracellular p75 in native configurations.
reconstitution
Reconstitute in 100 Aul of sterile water. Centrifuge to remove any insoluble material.
specificreferences
Panni P, Ferguson IA, Beacham I, Mackay-Sim A, Ekberg JA, John JA. (2013) "Phagocytosis of bacteria by olfactory ensheathing cells and Schwann cells" Neurosci Lett. 2013 Feb 13. pii: S0304-3940(13)00109-2. Application: Immunopanning, species: Mouse

Zhang C. et al (2012) Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cells PLoS One. 2012, 7(1)

Wiese S, Herrmann T, Drepper C, Jablonka S, Funk N, Klausmeyer A, Rogers ML, Rush RA & Sendtner M (2009) Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos. Nat Protoc. 2010, 5(1):31-8.

Chacón PJ, ArÃvalo MA, TÃbar AR. (2010) NGF-activated protein tyrosine phosphatase 1B mediates the phosphorylation and degradation of I-kappa-Balpha coupled to NF-kappa-B activation, thereby controlling dendrite morphology. Mol Cell Neurosci. 2010 Apr, 43(4):384-93.

Selvaraj BT et al (2012) Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease. J Cell Biol. 2012 Oct 29, 199(3):437-51.

Rogers ML et al (2010) ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex. J Neuroimmunol. 2010 Sep 14, 226(1-2):93-103.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100ug
Lieferbar: In stock
lieferbar

Vergleichen

Auf den Wunschzettel

Angebot anfordern

Lieferzeit anfragen

Technische Frage stellen

Bulk-Anfrage stellen

Fragen zum Produkt?
 
Schließen