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Sheep antibody to Connexin-37 (265-280): whole serum

Sheep antibody to Connexin-37 (265-280): whole serum

ArtNr	S-062-100
Hersteller	Biosensis
Menge	100ul
Kategorie	Neuroscience Protein Aggregation, Clearance & Misfolding Antibodies Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody
Applikationen	WB, IF
Specific against	other
Host	Sheep
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Gja4, Gap junction alpha-4 protein, Cx37, Cxn-37
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Sub category	Receptors & Channel Molecules
products_extra_fields_value	FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Connexin-37 may also mediate hyperexcitability followin nerve injury. SUBUNIT: A connexon is composed of a hexamer of connexins. SUBCELLULAR LOCATION: Membrane, multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in lung. SIMILARITY: Belongs to the connexin family. Alpha-type (group II) subfamily.
products_quantity	200
storage	After reconstitution keep aliquots at -20AC for a higher stability, and at 4AC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
purityisotype	Whole serum
formulation	Lyophilised
immunogen	A synthetic peptide (YLPMGE GPSSPPCPTY) as part of rat Connexin-37 protein (aa: 265-280) conjugated to diphtheria toxoid
crossreactivity	This antiserum recognises rat and mouse Connexin-37 protein.
conality	Sheep
specificity	Western blotting of cell membarnes of COS cells transiently transfected with cDNA encoding Connexin-37 shows two bands of molecular weight 36 and 37 kDa which are abolished by preincubation with the immunising peptide. No such bands are detected in western blots of membranes from non-transfected cells or cells transfected with cDNA encoding Connexin-40, Connexin-43 or Connexin-45.
reconstitution	Reconstitute in 100 Aul of sterile water. Centrifuge to remove any insoluble material.

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