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Recombinant Human HtrA3, His - tagged Europäischer Partner

ArtNr BTZ-30600502
Hersteller BioTeZ
Menge 5 ug/50 ul
Kategorie
Typ Proteins Recombinant
Format Liquid
Specific against Human (Homo sapiens)
Protein Familie Member of the trypsin family of serine proteases
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Lieferbar
Purity
> 70 %
Product Subcategory
EC 3.4.21.108
Pathway and Disease
Diseases associated with HTRA3 include Vitreoretinopathy, Neovascular Inflammatory and Purulent Acute Otitis Media, Preeclampsia
Description
HtrA3 is a serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization
Applications Info
Characterization of structure and function, Screening of inhibitors, Standard in enzymatic and immunologiacal assays
Alternate Names
High-Temperature Requirement Factor A3, Pregnancy-Related Serine Protease
Sequence
MQARALLLAALAALALAREPPAAPCPARCDVSRCP SPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPC GESLECVRGLCRCRWSHAVCGTDGHTYANVCALQA ASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSG SGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG HSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRE GRELGLRDSDMDYIQTDAIIHHHHHH
Accession No
P83110
Composition
150 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35, 50 mM imidazol, 50 mM Tris-HCl, pH 7.5.
Storage
Store at -70C
Target Modification
No
Expression System
Insect Cell
Product Subtype
full length
Active?
Yes
Tag
His-tagged
Gene ID
94031
Molecular Weight
50 kDa
Shipping Temp Min
dry ice
Product description long
Recombinant human HtrA3 is expressed in insect cells with a C-terminal His-tag and purified from insect cell culture supernatants
Purification
Mentioned in the data sheet
Restrictions
For Research Use only.
NCBI Official Symbol
HTRA3

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 5 ug/50 ul
Lieferbar: In stock
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