alpha2-Macroglobulin (A2M)

Diseases associated with A2M include Alzheimer Disease and Alpha-2-Macroglobulin Deficiency. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade)

alpha2-Macroglobulin human is used to inhibit matrix metalloproteinases and serine proteases and to use to active site titration

MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLV PSLLHTETTEKGCVLLSYLNETVTVSASLESVRGN RSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTV QVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKP GQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRI AQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQKK SGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEE MNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHG EDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKE YEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKL SFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIF IRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLT VRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPS KSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGL KKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFS ISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDV ENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVC ALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGF PGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKD MYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGP EGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYF PETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAF CLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRG EAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVE KEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAE ALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGL EKETTFNSLLCPSGGEVSEELSLKLPPNVVEESAR ASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLF APNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQ LNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFA QARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGS LLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPV VRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFA LAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPK APVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTS EDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHA LSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNN NRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKY NILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISL SVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLE RSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQ DVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKD LGNA

50 mM phosphate buffer pH 7.4; 100mM NaCl, 500 ug glycine

Yes

full length

untagged

725 kDa

Prepared from human blood.

For Research Use only.