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alpha2-Macroglobulin (A2M)

alpha2-Macroglobulin (A2M)

Item no.	BTZ-30900104
Manufacturer	BioTeZ
Amount	1 mg
Category	Neuroscience Aging & Neurological Disorders Peptides & Proteins Native Proteins
Type	Proteins Native
Format	Liquid
Specific against	Human (Homo sapiens)
Protein Family	Protease inhibitor and cytokine transporter
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Purity	>90% ; trace amount of IgM
Pathway and Disease	Diseases associated with A2M include Alzheimer Disease and Alpha-2-Macroglobulin Deficiency. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade)
Description	A2M able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Applications Info	alpha2-Macroglobulin human is used to inhibit matrix metalloproteinases and serine proteases and to use to active site titration
Alternate Names	C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 5
Sequence	MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLV PSLLHTETTEKGCVLLSYLNETVTVSASLESVRGN RSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTV QVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKP GQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRI AQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQKK SGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEE MNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHG EDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKE YEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKL SFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIF IRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLT VRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPS KSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGL KKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFS ISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDV ENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVC ALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGF PGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKD MYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGP EGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYF PETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAF CLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRG EAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVE KEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAE ALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGL EKETTFNSLLCPSGGEVSEELSLKLPPNVVEESAR ASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLF APNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQ LNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFA QARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGS LLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPV VRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFA LAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPK APVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTS EDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHA LSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNN NRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKY NILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISL SVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLE RSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQ DVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKD LGNA
Accession No	P01023
Composition	50 mM phosphate buffer pH 7.4; 100mM NaCl, 500 ug glycine
Storage	Store at -70C
Target Modification	Yes
Expression System	Human Blood
Product Subtype	full length
Active?	Yes
Tag	untagged
Gene ID	2
Molecular Weight	725 kDa
Shipping Temp Min	cool packs or dry ice
Product description long	Prepared from human blood.
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	A2M

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 10/30/2025

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