alpha1- Antitrypsin

ArtNr	BTZ-30900105
Hersteller	BioTeZ
Menge	1 mg
Kategorie	Food Safety Proteins Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Cardiovascular Research Hypertension Native Proteins
Typ	Proteins Native
Format	Liquid
Specific against	Human (Homo sapiens)
Protein Familie	Inhibitor of serine proteases, Member of Serpin Family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Purity	>95%
Pathway and Disease	Diseases associated with SERPINA1 include Emphysema Due To Aat Deficiency and Hemorrhagic Disease Due To Alpha-1-Antitrypsin Pittsburgh Mutation. Among its related pathways are Platelet activation, signaling and aggregation and FOXA1 transcription factor network.
Description	SERPIN1's primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Applications Info	inhibitor of proteases
Alternate Names	Serpin Family A Member 1, Serpin Peptidase Inhibitor, Clade A,
Sequence	MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKT DTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSN STNIFFSPVSIATAFAMLSLGTKADTHDEILEGLN FNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGN GLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTE EAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVN YIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMM KRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPD EGKLQHLENELTHDIITKFLENEDRRSASLHLPKL SITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAP LKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIP PEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
Accession No	P01009
Composition	50mM phosphate buffer pH 6.5; 100mM NaCl, without BSA and Azide
Storage	Store at -70C
Target Modification	No
Expression System	Human Blood
Product Subtype	full length
Active?	Yes
Tag	untagged
Gene ID	5265
Molecular Weight	54 kDa
Shipping Temp Min	cool packs or dry ice
Product description long	Purified from human serum.
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	SERPINA1

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Menge: 1 mg

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