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Cytokeratin 5 (S573) polyclonal antibody

Cytokeratin 5 (S573) polyclonal antibody

Hersteller	Bioworld Technology, Inc
Kategorie	Antibodies Cell Biology Cytoskeleton Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Intermediate filaments
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applikationen	WB, IF, IHC
Menge	100ul
Host	Rabbit
ArtNr	BS1208-100
eClass 6.1	32160702
eClass 9.0	32160702
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Swiss-Prot	P13647
Application all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200
Background	Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin 5 gene (KRT5) have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB).
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	Cytokeratin 5 (S573) pAb detects endogenous levels of Cytokeratin 5 protein.
IHC	Immunohistochemistry (IHC) analyzes of Cytokeratin 5 (S573) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
BiowMW	ca. 62 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Keratin, type II cytoskeletal 5, 58 kDa cytokeratin, Cytokeratin-5, Cytokeratin5, Short name=CK-5, CK5, Keratin-5, Keratin5, Keratin 5, Short name=K5, Type-II keratin Kb5, KRT5
Immunogen	Synthetic peptide, corresponding to amino acids 550-600 of Human Cytokeratin 5.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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