ACE (F940) polyclonal antibody

P12821

Angiotensin-converting enzyme (ACE) is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically, late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in fluid/electrolyte homeostasis.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

ACE (F940) pAb detects endogenous levels of Angiotensin-converting enzyme protein.

Immunohistochemistry (IHC) analyzes of ACE (F940) pAb in paraffin-embedded human brain tissue.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to amino acids 920-950 of Human ACE.