Cytokeratin 14 (Y151) polyclonal antibody

P02533

Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and in addition they aid in the characterization of malignant tumors. In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Cytokeratin 14 (Y151) pAb detects endogenous levels of Cytokeratin 14 protein.

ca. 52 kDa

Keratin, type I cytoskeletal 14, Cytokeratin-14, Short name=CK-14, Keratin-14, Short name=K14, KRT14, CK-14, CK 14, CK14, Cytokeratin-14, Cytokeratin 14, Cytokeratin14,