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Cytokeratin 14 (Y151) polyclonal antibody

Cytokeratin 14 (Y151) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Antibodies Cell Biology Cytoskeleton Immunohistochemistry Primary Antibodies Intermediate filaments
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	IHC
Amount	100ul
Host	Rabbit
Item no.	BS3500-100
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	P02533
Application all	IHC: 1:50ca.1:200
Background	Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and in addition they aid in the characterization of malignant tumors. In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	Cytokeratin 14 (Y151) pAb detects endogenous levels of Cytokeratin 14 protein.
IHC	Immunohistochemistry (IHC) analyzes of Cytokeratin 14 (Y151) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
BiowMW	ca. 52 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Keratin, type I cytoskeletal 14, Cytokeratin-14, Short name=CK-14, Keratin-14, Short name=K14, KRT14, CK-14, CK 14, CK14, Cytokeratin-14, Cytokeratin 14, Cytokeratin14,
Immunogen	Synthetic peptide, corresponding to amino acids 111-160 of Human Cytokeratin 14.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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