SOCS-1 (V98) polyclonal antibody

O15524

The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction. The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the "SOCS box." The SOCS-1 (also called SSI-1 and JAB), SOCS-2 (also called SSI-2 and CIS2) and SOC-3 (also called SSI-3 and CIS3) genes are known to be upregulated by IL-6 and other cytokines. SOCS-4, SOCS-5, SOCS-6 and SOCS-7 were identified by their sequence homology with the SOCS box. CIS (for cytokine-inducible SH2-containing protein) is also a member of the SOCS family.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

SOCS-1 (V98) pAb detects endogenous levels of SOCS-1 protein.

ca. 38 kDa

Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, Short name=JAB, STAT-induced STAT inhibitor 1, Short name=SSI-1, Tec-interacting protein 3, TIP-3, SSI1, TIP3, SOCS1