Manufacturer |
Bioworld Technology, Inc
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Applications |
WB |
Amount |
50ul |
Host |
Rabbit |
Item no. |
BS3509-50 |
Targets |
SOAT1;;SOCS1 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Swiss-Prot |
O15524 |
Application all |
WB: 1:500ca.1:1000 |
Background |
The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction. The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the "SOCS box." The SOCS-1 (also called SSI-1 and JAB), SOCS-2 (also called SSI-2 and CIS2) and SOC-3 (also called SSI-3 and CIS3) genes are known to be upregulated by IL-6 and other cytokines. SOCS-4, SOCS-5, SOCS-6 and SOCS-7 were identified by their sequence homology with the SOCS box. CIS (for cytokine-inducible SH2-containing protein) is also a member of the SOCS family. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
SOCS-1 (V98) pAb detects endogenous levels of SOCS-1 protein. |
WB |
Western blot (WB) analysis of SOCS-1 (V98) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate |
BiowMW |
ca. 38 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, Short name=JAB, STAT-induced STAT inhibitor 1, Short name=SSI-1, Tec-interacting protein 3, TIP-3, SSI1, TIP3, SOCS1 |
Immunogen |
Synthetic peptide, corresponding to amino acids 71-120 of Human SOCS-1. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.