Background |
Myosin regulatory light chains, including MRCL3 (also known as MRLC3 or MLCB), MRLC2 (also known as MLC-B) and MYL9 (also known as LC20, MLC2, MRLC1 or MYRL2), regulate contraction in smooth muscle and non-muscle cells via phosphorylation by myosin light chain kinase (MLCK). Phosphorylation of myosin regulatory light chains, catalyzed by MLCK in the presence of calcium and calmodulin, increases the Actin-activated myosin ATPase activity, thereby regulating the contractile activity. Myosin light chain is also located in striated skeletal muscle, where its function remains undefined. |
WB |
Western blot (WB) analysis of p-MYL9 (S19) pAb at 1:500 dilution Lane1:LO2 cell lysate treated with EGF(EGF, 0.1ng/ML, 30min) Lane2:Raw264.7 cell lysate treated with EGF(EGF, 0.1ng/ML, 30min) Lane3:Rat heart tissue lysate |
Alternative Name |
Myosin regulatory light polypeptide 9, 20 kDa myosin light chain, Short name=LC20, MLC-2C, Myosin RLC, Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9, Myosin regulatory light chain MRLC1, MLC2, MRLC1, MYRL2, Myosin regulatory light chain 12A, MLC-2B, Myosin RLC, Myosin regulatory light chain 2, nonsarcomeric, Myosin regulatory light chain MRLC3, MYL12A, MLCB, MRLC3, RLC |