Anti-STAT3 Antibody

Primary Antibodies

88068 MW

STAT3 antibody can be used for detection of STAT3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Signal transducer and activator of transcription 3 (acute-phase response factor)

Rabbit polyclonal STAT3 antibody was raised against a 19amino acid peptide near the amino terminus of human STAT3. The immunogen is located within amino acids 170 - 220 of STAT3.

STAT3 Antibody is affinity chromatography purified via peptide column.

Signal Transduction

Signal transducer and transcription activator that
mediates cellular responses to interleukins, KITLG/SCF, LEP and
other growth factors (PubMed:10688651, PubMed:12359225,
PubMed:12873986, PubMed:15194700, PubMed:17344214,
PubMed:18242580, PubMed:23084476). Once activated, recruits
coactivators, such as NCOA1 or MED1, to the promoter region of the
target gene (PubMed:17344214). May mediate cellular responses to
activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds
to the interleukin-6 (IL-6)-responsive elements identified in the
promoters of various acute-phase protein genes (PubMed:12359225).
Activated by IL31 through IL31RA (PubMed:15194700). Acts as a
regulator of inflammatory response by regulating differentiation
of naive CD4 (+) T-cells into T-helper Th17 or regulatory T-cells
(Treg): deacetylation and oxidation of lysine residues by LOXL3,
leads to disrupt STAT3 dimerization and inhibit its transcription
activity (PubMed:28065600). Involved in cell cycle regulation by
inducing the expression of key genes for the progression from G1
to S phase, such as CCND1 (PubMed:17344214). Mediates the effects
of LEP on melanocortin production, body energy homeostasis and
lactation (By similarity). May play an apoptotic role by
transctivating BIRC5 expression under LEP activation
(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by
inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial
role in basal beta cell functions, such as regulation of insulin
secretion (By similarity).

Boster Bio Anti-STAT3 Antibody (Catalog # A00007-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Bovine, Pig, Chicken