Anti-VHL Antibody

ArtNr	BOS-A00079
Hersteller	Boster
Menge	100 ul
Quantity options	100 ul 100 ul 100 ul/vial
Kategorie	Oncology By Cell Type Carcinoma Glioma Hematology Lymphoma Myeloma Western Blot
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Alias	von Hippel-Lindau disease tumor suppressor,Protein G7,pVHL,VHL
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	24153 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:1000
Gene Name	VHL
Gene Full Name	von Hippel-Lindau disease tumor suppressor
Immunogen	A synthetic peptide corresponding to residues in Human VHL.
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	von Hippel-Lindau disease tumor suppressor
Protein Function	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Subcellular Localization	Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.
Description	Boster Bio Anti-VHL Antibody catalog # A00079. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in the adult and fetal brain and kidney.

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Arbeitsanleitung (Data Sheet) anfordern

BOS-A00079-datasheet.pdf

BOS-A00079-safety-datasheet.pdf