Anti-RNF2 Antibody

Primary Antibodies

37655 MW

WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:50-1:200
ChIP: 1:50-1:200

E3 ubiquitin-protein ligase RING2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

E3 ubiquitin-protein ligase that mediates
monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub),
thereby playing a central role in histone code and gene regulation
(PubMed:15386022, PubMed:16359901, PubMed:25519132,
PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub
gives a specific tag for epigenetic transcriptional repression and
participates in X chromosome inactivation of female mammals. May
be involved in the initiation of both imprinted and random X
inactivation (By similarity). Essential component of a Polycomb
group (PcG) multiprotein PRC1-like complex, a complex class
required to maintain the transcriptionally repressive state of
many genes, including Hox genes, throughout development
(PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via
chromatin remodeling and modification of histones, rendering
chromatin heritably changed in its expressibility
(PubMed:26151332). E3 ubiquitin-protein ligase activity is
enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3
ubiquitin ligase on histone H2A of the PRC1 complex, while RING1
may rather act as a modulator of RNF2/RING2 activity (Probable).
Association with the chromosomal DNA is cell-cycle dependent. In
resting B- and T-lymphocytes, interaction with AURKB leads to
block its activity, thereby maintaining transcription in resting
lymphocytes (By similarity).

Boster Bio Anti-RNF2 Antibody catalog # A01209-2. Tested in WB, IHC, ICC/IF, IP, ChIP applications. This antibody reacts with Human, Mouse, Rat.