Comparison

Anti-RNF2 Antibody European Partner

Item no. BOS-A01209-2
Manufacturer Boster
Amount 100 ul
Category
Format Liquid
Applications WB, IF, IP, IHC, ICC, CHIP
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Alias E3 ubiquitin-protein ligase RING2,2.3.2.27
Available
Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight
37655 MW
Clonality
Polyclonal
Application Details
WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:50-1:200
ChIP: 1:50-1:200
Gene Name
RNF2
Gene Full Name
E3 ubiquitin-protein ligase RING2
Immunogen
Recombinant fusion protein of human RING1B/RING1B/RNF2(NP_009143.1).
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration
1 mg/ml
Protein Name
E3 ubiquitin-protein ligase RING2
Protein Function
E3 ubiquitin-protein ligase that mediates
monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub),
thereby playing a central role in histone code and gene regulation
(PubMed:15386022, PubMed:16359901, PubMed:25519132,
PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub
gives a specific tag for epigenetic transcriptional repression and
participates in X chromosome inactivation of female mammals. May
be involved in the initiation of both imprinted and random X
inactivation (By similarity). Essential component of a Polycomb
group (PcG) multiprotein PRC1-like complex, a complex class
required to maintain the transcriptionally repressive state of
many genes, including Hox genes, throughout development
(PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via
chromatin remodeling and modification of histones, rendering
chromatin heritably changed in its expressibility
(PubMed:26151332). E3 ubiquitin-protein ligase activity is
enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3
ubiquitin ligase on histone H2A of the PRC1 complex, while RING1
may rather act as a modulator of RNF2/RING2 activity (Probable).
Association with the chromosomal DNA is cell-cycle dependent. In
resting B- and T-lymphocytes, interaction with AURKB leads to
block its activity, thereby maintaining transcription in resting
lymphocytes (By similarity).
Subcellular Localization
Nucleus
Description
Boster Bio Anti-RNF2 Antibody catalog # A01209-2. Tested in WB, IHC, ICC/IF, IP, ChIP applications. This antibody reacts with Human, Mouse, Rat.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
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