Anti-ADP-ribosylation factor 1 ARF1 Antibody

Primary Antibodies

20697 MW

WB: 1:500-1:2000
IF: 1:50-1:200

ADP-ribosylation factor 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

GTP-binding protein involved in protein trafficking
among different compartments. Modulates vesicle budding and
uncoating within the Golgi complex. Deactivation induces the
redistribution of the entire Golgi complex to the endoplasmic
reticulum, suggesting a crucial role in protein trafficking. In
its GTP-bound form, its triggers the association with coat
proteins with the Golgi membrane. The hydrolysis of ARF1-bound
GTP, which is mediated by ARFGAPs proteins, is required for
dissociation of coat proteins from Golgi membranes and vesicles.
The GTP-bound form interacts with PICK1 to limit PICK1-mediated
inhibition of Arp2/3 complex activity; the function is linked to
AMPA receptor (AMPAR) trafficking, regulation of synaptic
plasicity of excitatory synapses and spine shrinkage during long-
term depression (LTD).

Boster Bio Anti-ADP-ribosylation factor 1 ARF1 Antibody catalog # A01279. Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.