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Anti-Neuropeptide S/NPS Antibody

Anti-Neuropeptide S/NPS Antibody

ArtNr	BOS-A01290-1-PE
Hersteller	Boster
Menge	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie	Metabolism Regulation of Appetite Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	IHC
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	PE
Citations	1. Meis S, Bergado-Acosta JR, Yanagawa Y, Obata K, Stork O, Munsch T (2008). Grothe B, ed. Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus. PloS One. 3 (7): e2695. 2. Reinscheid RK, Xu YL (Dec 2005). Neuropeptide S and its receptor: a newly deorphanized G protein-coupled receptor system. The Neuroscientist. 11 (6): 532–8.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Neuropeptide S,NPS
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Molecular Weight	19 kDa
Clonality	Polyclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Mouse, Rat
Gene Name	NPS
Gene Full Name	neuropeptide S
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Neuropeptide S (NPS) is a neuropeptide found in human and mammalian brain, mainly produced by neurons in the amygdala and between Barrington's nucleus and the locus coeruleus, although NPS-responsive neurons extend projections into many other brain areas. NPS binds specifically to a G protein-coupled receptor, NPSR. Animal studies show that NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality, and plays a significant role in the extinction of conditioned fear.It has also been shown to significantly enhance dopamine activity in the mesolimbic pathway, and inhibits motility and increases permeability in neurocrine fashion acting through NO in the myenteric plexus in rats and humans.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Neuropeptide S, which shares 80% amino acid (aa) sequence identity with both mouse and rat Neuropeptide S.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Chemical Type, Signal Transduction
Protein Function	Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Description	Boster Bio Anti-Neuropeptide S/NPS Antibody Picoband® catalog # A01290-1. Tested in IHC applications. This antibody reacts with Mouse, Rat.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

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BOS-A01290-1-PE-datasheet.pdf

BOS-A01290-1-PE-safety-datasheet.pdf