Anti-Trk B (phospho-Y515) NTRK2 Antibody

Primary Antibodies

91999 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

BDNF/NT-3 growth factors receptor

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Receptor tyrosine kinase involved in the development and
the maturation of the central and the peripheral nervous systems
through regulation of neuron survival, proliferation, migration,
differentiation, and synapse formation and plasticity. Receptor
for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-
4. Alternatively can also bind NTF3/neurotrophin-3 which is less
efficient in activating the receptor but regulates neuron survival
through NTRK2. Upon ligand-binding, undergoes homodimerization,
autophosphorylation and activation. Recruits, phosphorylates
and/or activates several downstream effectors including SHC1,
FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping
signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the
GRB2-Ras-MAPK cascade that regulates for instance neuronal
differentiation including neurite outgrowth. Through the same
effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that
mainly regulates growth and survival. Through PLCG1 and the
downstream protein kinase C-regulated pathways controls synaptic
plasticity. Thereby, plays a role in learning and memory by
regulating both short term synaptic function and long-term
potentiation. PLCG1 also leads to NF-Kappa-B activation and the
transcription of genes involved in cell survival. Hence, it is
able to suppress anoikis, the apoptosis resulting from loss of
cell-matrix interactions. May also play a role in neutrophin-
dependent calcium signaling in glial cells and mediate
communication between neurons and glia.

Boster Bio Anti-Trk B (phospho-Y515) NTRK2 Antibody catalog # A01388Y515. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.