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Anti-ARHGEF5 Antibody

Anti-ARHGEF5 Antibody

ArtNr	BOS-A01487
Hersteller	Boster
Menge	100 ul
Quantity options	100 ul 100 ul
Kategorie	Neuroscience Neural Signaling Antibodies Cell Biology Cytoskeleton Western Blot Primary Antibodies small GTPases Rho Subfamily
Typ	Antibody
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Rho guanine nucleotide exchange factor 5,Ephexin-3,Guanine nucleotide regulatory protein TIM,Oncogene TIM,Transforming immortalized mammary oncogene,p60 TIM,ARHGEF5,TIM
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	176799 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:1000
Gene Name	ARHGEF5
Gene Full Name	Rho guanine nucleotide exchange factor 5
Immunogen	Synthetic peptide, corresponding to amino acids 1310-1355 of Human ARHGEF5.
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	Rho guanine nucleotide exchange factor 5
Protein Function	Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity).
Subcellular Localization	Cytoplasm
Description	Boster Bio Anti-ARHGEF5 Antibody catalog # A01487. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653).

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-A01487-datasheet.pdf

BOS-A01487-safety-datasheet.pdf