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Anti-5-HT2C Receptor/HTR2C Antibody Picoband® Europäischer Partner

ArtNr BOS-A01593-1-APC
Hersteller Boster
Menge 100 ug
Quantity options 100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie
Typ Antibody
Format Lyophilized
Applikationen WB, ELISA
Specific against Human (Homo sapiens), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Konjugat/Tag APC
Citations 1. Brennan, T. J., Seeley, W. W., Kilgard, M., Schreiner, C. E., Tecott, L. H. Sound-induced seizures in serotonin 5-HT-2C receptor mutant mice. Nature Genet. 16: 387-390, 1997.
2. Di Narzo, A. F., Kozlenkov, A., Roussos, P., Hao, K., Hurd, Y., Lewis, D. A., Sibille, E., Siever, L. J., Koonin, E., Dracheva, S. A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide. Hum. Molec. Genet. 23: 4801-4813, 2014.
3. Doe, C. M., Relkovic, D., Garfield, A. S., Dalley, J. W., Theobald, D. E. H., Humby, T., Wilkinson, L. S., Isles, A. R. Loss of imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT(2C)R-mediated behaviour. Hum. Molec. Genet. 18: 2140-2148, 2009.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Lieferbar
Manufacturer - Category
Primary Antibodies
Storage Conditions
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Observed Molecular weight
75 kDa
Calculated Molecular weight
34140 MW
Clonality
Polyclonal
Application Details
Western blot, 0.25-0.5 μg/ml, Rat
ELISA, 0.1-0.5 μg/ml
Gene Name
HTR2C
Gene Full Name
neutrophil cytosolic factor 1
Background
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.
Immunogen
E.coli-derived human 5-HT2C Receptor/HTR2C recombinant protein (Position: N372-V458).
Contents
Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification
Immunogen affinity purified.
Reconstitution
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category
Cancer, Cancer Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Protein Name
Growth/differentiation factor 15
Protein Function
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Subcellular Localization
Cytoplasm, cytosol.
Description
Boster Bio Anti-5-HT2C Receptor/HTR2C Antibody Picoband® catalog # A01593-1. Tested in ELISA, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity
Detected in peripheral blood monocytes and neutrophils (at protein level).
Manufacturer - Alias
Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, p47-phox, NCF1, NOXO2, SH3PXD1A

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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