Anti-CIDE-A Antibody

ArtNr	BOS-A02671
Hersteller	Boster
Menge	0.1 mg
Quantity options	0.1 mg 0.1 mg
Kategorie	Metabolism Diabetes Glucose Homeostasis Obesity Immunohistochemistry Western Blot ELISA Immunofluorescence Immunostaining
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Alias	CIDE-A,Cell death activator CIDE-A,Cell death-inducing DFFA-like effector A
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	CIDE-A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	24687 MW
Clonality	Polyclonal
Application Details	CIDE-A antibody can be used for detection of CIDE-A by Western blot at 2 μg/mL. An approximately 23 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	CIDEA
Gene Full Name	Cell death-inducing DFFA-like effector a
Manufacturer - Specificity	It has no cross activity to CIDE-B.
Background	Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues.
Immunogen	CIDE-A antibody was raised against a 18 amino acid peptide near the carboxy terminus of human CIDE-A. The immunogen is located within the last 50 amino acids of CIDE-A.
Contents	CIDE-A Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	CIDE-A Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/ml
Manufacturer - Research Category	Apoptosis
Protein Name	Cell death-inducing DFFA-like effector a
Protein Function	Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
Subcellular Localization	Lipid droplet
Description	Boster Bio Anti-CIDE-A Antibody (Catalog # A02671). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Tissue Specificity	Expressed in omental and subcutaneous adipose tissue (at protein level).
Manufacturer - Cross Reactivity	It has no cross activity to CIDE-B.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

BOS-A02671-datasheet.pdf

BOS-A02671-safety-datasheet.pdf