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Anti-CES2 Antibody (Center)

Anti-CES2 Antibody (Center)

ArtNr	BOS-A02868-1-400ul
Hersteller	Boster
Menge	400 ul
Quantity options	400 ul 80 ul
Kategorie	Metabolism Cholesterol & Lipid Metabolism Flow Cytometry Immunohistochemistry Western Blot Enzymes Other Fatty Acid Enzymes
Applikationen	WB, FC, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Alias	Cocaine esterase,Carboxylesterase 2,CE-2,hCE-2,Methylumbelliferyl-acetate deacetylase 2,CES2,ICE
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	61807 Da
Clonality	Polyclonal
Application Details	WB: 1:2000 IHC-P: 1:50-1:100 FC: 1:25
Gene Name	CES2
Background	CES2 is a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance.
Immunogen	This CES2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-369 amino acids from the Central region of human CES2.
Contents	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Manufacturer - Research Category	Metabolism, Signal Transduction
Protein Function	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2- arachidonoylglycerol and prostaglandins (PubMed:21049984).
Subcellular Localization	Endoplasmic reticulum lumen
Description	Boster Bio Anti-CES2 Antibody (Center) (Catalog # A02868-1). Tested in WB, IHC-P, Flow Cytometry application(s). This antibody reacts with Human.
Tissue Specificity	Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum

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BOS-A02868-1-400ul-datasheet.pdf

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