Anti-PKN1 Antibody

Primary Antibodies

103932 MW

WB: 1:500-1:1000
ICC: 1:50-1:200

Serine/threonine-protein kinase N1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

PKC-related serine/threonine-protein kinase involved in
various processes such as regulation of the intermediate filaments
of the actin cytoskeleton, cell migration, tumor cell invasion and
transcription regulation. Part of a signaling cascade that begins
with the activation of the adrenergic receptor ADRA1B and leads to
the activation of MAPK14. Regulates the cytoskeletal network by
phosphorylating proteins such as VIM and neurofilament proteins
NEFH, NEFL and NEFM, leading to inhibit their polymerization.
Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau,
lowering its ability to bind to microtubules, resulting in
disruption of tubulin assembly. Acts as a key coactivator of
androgen receptor (ANDR)-dependent transcription, by being
recruited to ANDR target genes and specifically mediating
phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific
tag for epigenetic transcriptional activation that promotes
demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.
Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their
import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-
159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to
phosphorylate RPS6 in vitro.

Boster Bio Anti-PKN1 Antibody catalog # A02879. Tested in WB, ICC applications. This antibody reacts with Human, Mouse, Rat.