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Anti-ENPP2 Antibody (Center)

Anti-ENPP2 Antibody (Center)

ArtNr	BOS-A03110-1-200ul
Hersteller	Boster
Menge	200 ul
Quantity options	200 ul 50 ul
Kategorie	Metabolism Cholesterol & Lipid Metabolism Flow Cytometry Western Blot Enzymes Fatty Acid Catabolism
Applikationen	WB, FC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Alias	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2,E-NPP 2,Autotaxin,Extracellular lysophospholipase D,LysoPLD,ENPP2,ATX,PDNP2
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	98994 Da
Clonality	Polyclonal
Application Details	WB: 1:2000 FC: 1:10-1:50
Gene Name	ENPP2
Background	ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This protein stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The protein is secreted and further processed to make the biologically active form.
Immunogen	This ENPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-406 amino acids from the Central region of human ENPP2.
Contents	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Manufacturer - Research Category	Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction
Protein Function	Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3- phosphocholine (lyso-PAF) (PubMed:21393252).
Subcellular Localization	Secreted
Description	Boster Bio Anti-ENPP2 Antibody (Center) (Catalog # A03110-1). Tested in WB, Flow Cytometry application(s). This antibody reacts with Human.
Tissue Specificity	Detected in blood plasma (at protein level) (PubMed:12176993, PubMed:26371182). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS) Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.

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BOS-A03110-1-200ul-datasheet.pdf

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