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Anti-JMJD2C Antibody (C-term)

Anti-JMJD2C Antibody (C-term)

ArtNr	BOS-A04689-400ul
Hersteller	Boster
Menge	400 ul
Quantity options	400 ul 80 ul
Kategorie	Oncology By Cell Type Flow Cytometry Western Blot
Applikationen	WB, FC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Alias	Lysine-specific demethylase 4C,11411-,Gene amplified in squamous cell carcinoma 1 protein,GASC-1 protein,JmjC domain-containing histone demethylation protein 3C,Jumonji domain-containing protein 2C,KDM4C,GASC1,JHDM3C,JMJD2C,KIAA0780
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	119982 Da
Clonality	Polyclonal
Application Details	WB: 1:2000 FC: 1:25
Gene Name	KDM4C
Background	This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
Immunogen	This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C.
Contents	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Manufacturer - Research Category	Cancer
Protein Function	Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Subcellular Localization	Nucleus {ECO:0000255\|PROSITE-ProRule:PRU00537}.
Description	Boster Bio Anti-JMJD2C Antibody (C-term) (Catalog # A04689). Tested in WB, Flow Cytometry application(s). This antibody reacts with Human, Mouse.
Tissue Specificity	Overexpressed in several esophageal squamous cell carcinomas (ESCs).

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-A04689-400ul-datasheet.pdf

BOS-A04689-400ul-safety-datasheet.pdf