Anti-USP30 Antibody

ArtNr	BOS-A06403-1
Hersteller	Boster
Menge	100 ul
Quantity options	100 ul 100 ul
Kategorie	Neuroscience Neuroinflammation Neural Mitochondrial Function Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ubiquitin carboxyl-terminal hydrolase 30,3.4.19.12,Deubiquitinating enzyme 30,Ubiquitin thioesterase 30,Ubiquitin-specific-processing protease 30,Ub-specific protease 30,USP30
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	58503 MW
Clonality	Polyclonal
Application Details	WB 1:500-1:2000 ELISA 1:10000
Gene Name	USP30
Gene Full Name	Ubiquitin carboxyl-terminal hydrolase 30
Immunogen	The antiserum was produced against synthesized peptide derived from human USP30. AA range:31-80
Contents	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Immunogen affinity purified
Concentration	1 mg/ml
Protein Function	Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
Subcellular Localization	Mitochondrion outer membrane.
Description	Boster Bio Anti-USP30 Antibody catalog # A06403-1. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in skeletal muscle, pancreas, liver and kidney.
Short Description	Boster Bio Anti-USP30 Antibody catalog # A06403-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

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BOS-A06403-1-datasheet.pdf

BOS-A06403-1-safety-datasheet.pdf