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Anti-LRRC32 Picoband® Antibody Europäischer Partner

ArtNr BOS-A08199-1-FITC
Hersteller Boster
Menge 100 ug
Quantity options 100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie
Typ Primary Antibody
Format Lyophilized
Applikationen WB, ELISA
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Konjugat/Tag FITC
Citations 1. Lienart, S., Merceron, R., Vanderaa, C., Lambert, F., Colau, D., Stockis, J., van der Woning, B., De Haard, H., Saunders, M., Coulie, P. G., Savvides, S. N., Lucas, S. Structural basis of latent TGF-beta-1 presentation and activation by GARP on human regulatory T cells. Science 362: 952-956, 2018.
2. Ollendorff, V., Noguchi, T., deLapeyriere, O., Birnbaum, D. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Diff. 5: 213-219, 1994.
3. Ollendorff, V., Szepetowski, P., Mattei, M.-G., Gaudray, P., Birnbaum, D. New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions. Mammalian Genome 2: 195-200, 1992.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Transforming growth factor beta activator LRRC32,Garpin,Glycoprotein A repetitions predominant,GARP,Leucine-rich repeat-containing protein 32,LRRC32,D11S833E
Lieferbar
Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight
72 kDa
Clonality
Polyclonal
Application Details
Western blot, 0.25-0.5μg/ml, Human
ELISA, 0.1-0.5μg/ml
Gene Name
LRRC32
Gene Full Name
leucine rich repeat containing 32
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant), is an 80 kDa type I transmembrane glycoprotein. It is mapped to 11q13.5. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
Immunogen
E.coli-derived human LRRC32 recombinant protein (Position: H20-R544).
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category
Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway
Protein Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).
Subcellular Localization
Cell membrane. Single-pass type I membrane protein. Cell surface.
Description
Boster Bio Anti-LRRC32 Picoband® Antibody catalog # A08199-1. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity
Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Manufacturer - Cross Reactivity
No cross-reactivity with other proteins.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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