Anti-GRK2 (T23) Antibody

Primary Antibodies

79574 MW

IHC: 1:50-1:200

Beta-adrenergic receptor kinase 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Specifically phosphorylates the agonist-occupied form of
the beta-adrenergic and closely related receptors, probably
inducing a desensitization of them. Key regulator of LPAR1
signaling. Competes with RALA for binding to LPAR1 thus affecting
the signaling properties of the receptor. Desensitizes LPAR1 and
LPAR2 in a phosphorylation-independent manner (PubMed:19306925,
PubMed:19715378). Positively regulates ciliary smoothened (SMO)-
dependent Hedgehog (Hh) signaling pathway by faciltating the
trafficking of SMO into the cilium and the stimulation of SMO
activity (By similarity).

Boster Bio Anti-GRK2 (T23) Antibody catalog # A32388T23. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.