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Anti-GRK2 (T23) Antibody

Anti-GRK2 (T23) Antibody

Item no.	BOS-A32388T23
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Molecular Targets for Neuroscience Immunohistochemistry Cardiovascular Research Heart Failure
Format	Liquid
Applications	IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Alias	Beta-adrenergic receptor kinase 1,Beta-ARK-1,2.7.11.15
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	79574 MW
Clonality	Polyclonal
Application Details	IHC: 1:50-1:200
Gene Name	GRK2
Gene Full Name	Beta-adrenergic receptor kinase 1
Immunogen	Synthetic peptide, corresponding to the N-terminal of Human GRK2.
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	Beta-adrenergic receptor kinase 1
Protein Function	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)- dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
Subcellular Localization	Cytoplasm
Description	Boster Bio Anti-GRK2 (T23) Antibody catalog # A32388T23. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in peripheral blood leukocytes.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A32388T23-datasheet.pdf

BOS-A32388T23-safety-datasheet.pdf