Anti-SOX2 Antibody

ArtNr	BOS-M00105-3-80ul
Hersteller	Boster
Menge	80 ul
Quantity options	400 ul 80 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Carcinoma Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Calcium Binding Protein Markers Interneuron Markers
Typ	Antibody Monoclonal
Applikationen	WB, FC, IF, IHC-P
Clon	57CT23.3.4
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Transcription factor SOX-2,SOX2
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	34310 Da
Clonality	Monoclonal
Application Details	IF: 1:10-1:50 WB: 1:4000 IHC-P: 1:50-1:100 FC: 1:10-1:50 IHC: 1:100
Gene Name	SOX2
Background	This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Immunogen	SOX2 recombinant protein is used to produce this monoclonal antibody.
Contents	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification	This antibody is purified through a protein G column, followed by dialysis against PBS.
Manufacturer - Research Category	Developmental Biology, Neuroscience, Signal Transduction
Protein Function	Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
Subcellular Localization	Nucleus speckle {ECO:0000250\|UniProtKB:Q05066}. Cytoplasm {ECO:0000250\|UniProtKB:Q05738}. Nucleus {ECO:0000250\|UniProtKB:Q05738}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity) {ECO:0000250\|UniProtKB:Q05066, ECO:0000250\|UniProtKB:Q05738}
Description	Boster Bio Anti-SOX2 Antibody (Catalog # M00105-3). Tested in WB, IF, Flow Cytometry, IHC-P application(s). This antibody reacts with Human.

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