Anti-Ki 67 MKI67 Monoclonal Antibody

Primary Antibodies

358694 MW

IHC 1:200-1000
WB 1:500-2000
IF 1:100-500
ELISA 1:1000-5000

Proliferation marker protein Ki-67

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Required to maintain individual mitotic chromosomes
dispersed in the cytoplasm following nuclear envelope disassembly
(PubMed:27362226). Associates with the surface of the mitotic
chromosome, the perichromosomal layer, and covers a substantial
fraction of the chromosome surface (PubMed:27362226). Prevents
chromosomes from collapsing into a single chromatin mass by
forming a steric and electrostatic charge barrier: the protein has
a high net electrical charge and acts as a surfactant, dispersing
chromosomes and enabling independent chromosome motility
(PubMed:27362226). Binds DNA, with a preference for supercoiled
DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the
internal structure of mitotic chromosomes (By similarity). May
play a role in chromatin organization (PubMed:24867636). It is
however unclear whether it plays a direct role in chromatin
organization or whether it is an indirect consequence of its
function in maintaining mitotic chromosomes dispersed (Probable).

Boster Bio Anti-Ki 67 MKI67 Monoclonal Antibody catalog # M00254-7. Tested in IHC, WB, IF, ELISA applications. This antibody reacts with Human.