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Anti-Glucagon Gcg Antibody (Monoclonal, K79bB10)

Anti-Glucagon Gcg Antibody (Monoclonal, K79bB10)

ArtNr	BOS-MA1047-10ug
Hersteller	Boster
Menge	10 ug
Quantity options	100 ug/vial 10 ug
Kategorie	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Immunohistochemistry Immunofluorescence Primary Antibodies
Typ	Antibody Monoclonal
Format	Lyophilized
Applikationen	IF, IHC
Clon	K79bB10
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus)
Host	Mouse
Isotype	IgG1
Sensitivity	>5000 cells
Citations	1. Schroeder, W. T.; Lopez, L. C.; Harper, M. E.; Saunders, G. F. : Localization of the human glucagon gene (GCG) to chromosome segment 2q36-37. Cytogenet. Cell Genet. 38: 76-79, 1984. 2. White, J. W.; Saunders, G. F. : Structure of the human glucagon gene. Nucleic Acids Res. 14: 4719-4730, 1986.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Glucagon,Glicentin,Glicentin-related polypeptide,GRPP,Oxyntomodulin,OXM,OXY,Glucagon,Glucagon-like peptide 1,GLP-1,Glucagon-like peptide 1 (7-37),GLP-1 (7-37),Glucagon-like peptide 1 (7-36),GLP-1 (7-36),Glucagon-like peptide 2,GLP-2,Gcg
Lieferbar
Manufacturer - Category	Primary Antibodies, Mouse Monoclonal Antibodies
Manufacturer - Isotype	Mouse IgG1
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Molecular Weight	50 kDa
Calculated Molecular weight	20846 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 1-2μg/ml, Human, mouse, rat, rabbit Immunofluorescence, 5 μg/ml, Human
Gene Name	GCG
Gene Full Name	Glucagon
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Glucagon is a member of a multigene family that includes secretin. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. The human glucagon gene is approximately 9.4 kb long and contains 6 exons and 5 introns, and assigned to 2q36-2q37.
Immunogen	Polymerized porcine glucagon.
Contents	Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Purification	Ascites
Reconstitution	Add 1 ml of PBS buffer will yield a concentration of 100ug/ml.
Concentration	Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
Manufacturer - Research Category	Cancer, Cancer Metabolism, Developmental Biology, Energy Transfer Pathways, Growth Factors/Hormones, Integration Of Energy, Integration Of Energy Metabolism, Lineage Markers, Lineage Specification, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Stem Cells, Tumor Biomarkers
Protein Name	Glucagon
Protein Function	Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
Subcellular Localization	Secreted.
Description	Boster Bio Anti-Glucagon Gcg Antibody (Monoclonal, K79bB10) catalog # MA1047. Tested in IF, IHC applications. This antibody reacts with Human, Mouse, Rabbit, Rat.
Tissue Specificity	Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract.
Sequence Similarities	Belongs to the glucagon family.

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BOS-MA1047-10ug-datasheet.pdf

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