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Anti-Galectin 1/LGALS1 Antibody PicobandÂ®

Anti-Galectin 1/LGALS1 Antibody PicobandÂ®

ArtNr	BOS-PA1422-APC
Hersteller	Boster
Menge	100 ug
Format	Lyophilized
Applikationen	WB, FC, IF, IHC, ICC, IHC-F
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	APC
Sensitivity	<10pg/ml
Citations	1. Gitt MA, Barondes SH (February 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry 30 (1): 82â€“9. 2. Gauthier L, Rossi B, Roux F, Termine E, Schiff C (October 2002). "Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering". Proc Natl Acad Sci U S A 99 (20): 13014â€“9. 3. Mehrabian, M., Gitt, M. A., Sparkes, R. S., Leffler, H., Barondes, S. H., Lusis, A. J.Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13.Genomics15: 418-420, 1993.
Alias	Galectin-1;Gal-1;14 kDa laminin-binding protein;HLBP14;14 kDa lectin;Beta-galactoside-binding lectin L-14-I;Galaptin;HBL;HPL;Lactose-binding lectin 1;Lectin galactoside-binding soluble 1;Putative MAPK-activating protein PM12;S-Lac lectin 1;LGALS1;
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Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20Â°C for one year from date of receipt. After reconstitution, at 4Â°C for one month. It can also be aliquotted and stored frozen at -20Â°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	15 kDa
Calculated Molecular weight	14716 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5Î¼g/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1Î¼g/ml, Human, By Heat Immunohistochemistry (Frozen Section), 0.5-1Î¼g/ml, Human Immunocytochemistry/Immunofluorescence, 2Î¼g/ml, Human Flow Cytometry (Fixed), 1-3Î¼g/1x10⁶ cells, Human
Manufacturer - Gene Name	LGALS1
Gene Full Name	Galectin-1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. Galectins belong to a family of related beta-galactoside-binding lectins, also referred to as S-type or S-Lac lectins. Its gene is mapped to 22q12-q13. Galectin-1 was expressed in a subset of slowly dividing subventricular zone astrocytes, which included the neural stem cells. It has been considered as an autocrine negative growth factor that regulates cell proliferation.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Galectin 1, different from the related rat and mouse sequences by one amino acid.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.01mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Manufacturer - Research Category	Cell Biology
Protein Name	Galectin-1(Gal-1)
Protein Function	May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Subcellular Localization	Secreted, extracellular space, extracellular matrix.
Description	Boster Bio Anti-Galectin 1/LGALS1 Antibody catalog # PA1422. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
Sequence Similarities	Contains 1 galectin domain.

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Menge: 100 ug

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