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Anti-Fatty Acid Synthase/FASN Antibody Picoband®

Anti-Fatty Acid Synthase/FASN Antibody Picoband®

ArtNr	BOS-PB9865-PE
Hersteller	Boster
Menge	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies By Cell Type Carcinoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Enzymes Fatty Acid Synthesis Primary Antibodies By Organ Lung Cancer Immunochemistry
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IF, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	PE
Sensitivity	<20 pg/ml
Citations	1. Entrez Gene: FASN fatty acid synthase. 2. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ (Oct 1995). Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci U S A 92 (19): 8695–9. 3. Smith S, Witkowski A, Joshi AK (July 2003). Structural and functional organization of the animal fatty acid synthase. Prog. Lipid Res. 42 (4): 289–317.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Fatty acid synthase,2.3.1.85,[Acyl-carrier-protein] S-acetyltransferase,2.3.1.38,[Acyl-carrier-protein] S-malonyltransferase,2.3.1.39,3-oxoacyl-[acyl-carrier-protein] synthase,2.3.1.41,3-oxoacyl-[acyl-carrier-protein] reductase,1.1.1.100,3-hydroxyacyl-[acyl-carrier-protein] dehydratase,4.2.1.59,Enoyl-[acyl-carrier-protein] reductase,1.3.1.39,Oleoyl-[acyl-carrier-protein] hydrolase,3.1.2.14,FASN,FAS
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	273 kDa
Calculated Molecular weight	273427 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml Immunocytochemistry/Immunofluorescence, 5 μg/ml Immunofluorescence, 5 μg/ml
Gene Name	FASN
Gene Full Name	Fatty acid synthase
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene. It is mapped to 17q25. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Immunogen	E. coli-derived human FASN recombinant protein (Position: M1-E226). Human FASN shares 90.3% and 90.7% amino acid (aa) sequence identity with mouse and rat FASN, respectively.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cancer, Cancer Metabolism, Cardiovascular, Energy Metabolism, Energy Transfer Pathways, Fatty Acid Oxidation, Fatty Acids, Integration Of Energy, Integration Of Energy Metabolism, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Neurology Process, Neuroscience, Obesity, Pathways and Processes, Redox Metabolism, Signal Transduction, Tumor Biomarkers
Protein Name	Fatty acid synthase
Protein Function	Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Subcellular Localization	Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Description	Boster Bio Anti-Fatty Acid Synthase/FASN Antibody Picoband® catalog # PB9865. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Ubiquitous. Prominent expression in brain, lung, and liver.
Manufacturer - Alias	Fatty acid synthase, 2.3.1.85, [Acyl-carrier-protein] S-acetyltransferase, 2.3.1.38, [Acyl-carrier-protein] S-malonyltransferase, 2.3.1.39, 3-oxoacyl-[acyl-carrier-protein] synthase, 2.3.1.41, 3-oxoacyl-[acyl-carrier-protein] reductase, 1.1.1.100, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, 4.2.1.59, Enoyl-[acyl-carrier-protein] reductase, 1.3.1.39, Oleoyl-[acyl-carrier-protein] hydrolase, 3.1.2.14, FASN, FAS
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

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BOS-PB9865-PE-datasheet.pdf

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