Human recombinant IGFBP7(IGF-binding protein 7) protein, AF

His-SUMO Tag (N-term)

The protein has a calculated MW of 38.18 kDa.
The protein migrates as 55 kDa under reducing condition (SDS-PAGE analysis).

The protein has a calculated MW of 38.18 kDa.The protein migrates as 55 kDa under reducing condition (SDS-PAGE analysis).

>95% as determined by SDS-PAGE.

IGFBP7, also known as mac25, prostacyclin-stimulating factor (PSF), tumor adhesion factor (TAF), and angiomodulin (AGM), is a secreted protein that belongs to the insulin-like growth factor (IGF)-binding protein (IGFBP) family. In contrast to the other family members, IGFBP7 binds IGFs through the N-terminal domain with low affinity. IGFBP7 is expressed in various human tissues, including the brain, liver, pancreas, and skeletal muscle, and is secreted into circulation. IGF-BP7 modulates many biological functions, such as protein synthesis, proliferation, anti-apoptosis, and cell survival. Moreover, it has been reported that IGFBP7 promotes cardiac senescence through IGF-1R/IRS/AKT-dependent suppression of FOXO3a, inhibiting DNA repair, subsequently the leading to the progression of Heart failure. Human and mouse IGFBP7 are highly homologous, sharing 94% a.a. sequence identity.

<1 EU per 1 μg of the protein by the LAL method.