Anti-SERCA2 ATPase/ATP2A2 Antibody Picoband®

Primary Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

114757 MW

Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

SERCA2 (SARCOPLASMIC RETICULUM Ca (2+)-ATPase 2), also called ATP2A2, ATP2B, encodes one of the SERCA Ca (2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. They are closely related to the plasma membrane Ca (2+)-ATPases, or PMCAs. SERCA2 belongs to the large family of P-type cation pumps that couple ATP hydrolysis with cation transport across membranes. The SERCA2 gene is mapped on 12q24.11. SERCA2 was expressed in all specimens, with pronounced expression in the subnuclear aspect of basal epidermal keratinocytes. There was variable suprabasal expression.SERCA2 expression was also observed in the infundibulum and outer root sheath of hair follicles; germinative and mature cells of sebaceous glands; secretory coil and duct of eccrine glands; apocrine gland cells; and arrector pili muscle. In Darier disease skin, strong SERCA2 positivity was detected in the basal, suprabasal, and acantholytic lesional cells. Perilesional Darier disease skin was comparable to normal skin.

Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

ATPases, Calcium Channels, Calcium Signaling, Cancer, Cardiovascular, Cofactors, Vitamins/Minerals, Contractility, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction, Signaling Pathway, Vitamins/Minerals

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.

Boster Bio Anti-SERCA2 ATPase/ATP2A2 Antibody catalog # PA1720. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.