Anti-Krueppel-like factor 5 KLF5 Antibody Picoband®

Primary Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

50792 MW

Western blot, 0.1-0.5?g/ml, Human

Krueppel-like factor 5

KLF5 (Krueppel-like factor 5) is a protein that in humans is encoded by the KLF5 gene. It is also known as BASIC TRANSCRIPTION ELEMENT-BINDING PROTEIN 2 or BTEB2. This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Suske et al. (2005)stated that the human KLF5 gene maps to chromosome 13q21.33, and the mouse Klf5 gene to chromosome 14E2.1. Sogawa et al. (1993)isolated a cDNA encoding BTEB2. The predicted 219-amino acid protein contains 3 consecutive zinc finger motifs near the C terminus. The zinc finger domains were 59% and 64% identical to those of Sp1 (189906) and BTEB1, respectively. Both BTEB2 and Sp1 have a short basic region preceding the zinc finger motifs that may play an auxiliary role in DNA binding. The N-terminal region of BTEB2 is proline rich. Recombinant BTEB2 protein and Sp1 showed very similar DNA-binding specificity in vitro. When expressed in mammalian cells, BTEB2 activated the transcription of a reporter gene fused to a GC box-containing promoter. Sogawa et al. (1993) also identified the rat BTEB2 homolog. Northern blot analysis of rat tissues revealed that BTEB2 is expressed only in the testis and placenta.

Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Apoptosis, Cancer, Cancer Susceptibility, Cardiovascular, Cell Biology, Domain Families, Epigenetics and Nuclear Signaling, Hypertrophy, Intracellular, Krueppel Like Factor, Mesenchymal Stem Cells, Oncoproteins, Oncoproteins/Suppressors, p53 Pathway, Proto-Oncogenes, Stem Cells, Transcription, Transcription Factors

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Boster Bio Anti-Krueppel-like factor 5 KLF5 Antibody catalog # PA1889. Tested in WB applications. This antibody reacts with Human.

Belongs to the krueppel C2H2-type zinc-finger protein family.