Anti-NRG1 Antibody Picoband®

ArtNr	BOS-PA1969
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Food Safety Allergenes Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IF, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
Citations	1. Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Lujan, R., Lloyd, K., Lerma, J., Marin, O., Rico, B. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464: 1376-1380, 2010. 2. Orr-Urtreger, A., Trakhtenbrot, L., Ben-Levy, R., Wen, D., Rechavi, G., Lonai, P., Yarden, Y. Neural expression and chromosomal mapping of NEU differentiation factor to 8p12-p21. Proc. Nat. Acad. Sci. 90: 1867-1871, 1993. 3. Steinthorsdottir, V., Stefansson, H., Ghosh, S., Birgisdottir, B., Bjornsdottir, S., Fasquel, A. C., Olafsson, O., Stefansson, K., Gulcher, J. R. Multiple novel transcription initiation sites for NRG1. Gene 342: 97-105, 2004.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Pro-neuregulin-1, membrane-bound isoform;Pro-NRG1;Neuregulin-1;Acetylcholine receptor-inducing activity;ARIA;Breast cancer cell differentiation factor p45;Glial growth factor;Heregulin;HRG;Neu differentiation factor;Sensory and motor neuron-derived factor;NRG1;GGF, HGL, HRGA, NDF, SMDF;
Similar products	heregulin, Acetylcholine receptor inducing activity antibody, Acetylcholine receptor-inducing activity antibody, ARIA antibody, Breast cancer cell differentiation factor p45 antibody, GGF antibody, GGF2 antibody, Glial growth factor antibody, heregulin antibody, alpha(45kD, ERBB2 p185-activator) antibody, HGL antibody, HRG antibody, HRG1 antibody, HRGA antibody, MST131 antibody, NDF antibody, Neu differentiation factor antibody, Neuregulin 1 antibody, neuregulin 1 type IV beta 1a antibody, neuregulin 1 type IV beta 3 antibody, Neuregulin-1 antibody, NRG 1 antibody, nrg1 antibody, NRG1_HUMAN antibody, OTTHUMP00000225398 antibody, OTTHUMP00000225419 antibody, OTTHUMP00000225420 antibody, OTTHUMP00000225421 antibody, OTTHUMP00000225422 antibody, OTTHUMP00000225477 antibody, OTTHUMP00000225545 antibody, OTTHUMP00000230603 antibody, OTTHUMP00000230605 antibody, Pro-NRG1 antibody, ProNRG1 antibody
Lieferbar
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	40, 65, 100 kDa
Calculated Molecular weight	70392 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5?g/ml, Human, By Heat Immunocytochemistry/Immunofluorescence, 2-5?g/ml, Human
Manufacturer - Gene Name	NRG1
Gene Full Name	Pro-neuregulin-1, membrane-bound isoform
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	NRG1 (Neuregulin 1), also known as ARIA, NDF or HRGA, is a protein that in humans is encoded by the NRG1 gene. NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. By in situ hybridization of a tritium-labeled probe to human metaphase spreads, Orr-Urtreger et al. (1993) localized the NDF gene to 8p21-p12. In mouse embryos 14.5 days postcoitum, Orr-Urtreger et al. (1993) found that NDF expression is confined predominantly to the central and peripheral nervous systems, including the neuroepithelium that lines the lateral ventricles of the brain, the ventral horn of the spinal cord, and the intestinal as well as dorsal root ganglia.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human NRG1, different from the related rat and mouse sequences by one amino acids.
Contents	Each vial contains 4 mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Growth and Development, Neurogenesis, Neurology Process, Neuroscience
Protein Name	Pro-neuregulin-1, membrane-bound isoform
Protein Function	ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
Subcellular Localization	Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.
Description	Boster Bio Anti-NRG1 Antibody catalog # PA1969. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.
Sequence Similarities	Belongs to the neuregulin family.

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